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Nya rön om hur ketamin får sin antidepressiva effekt

The experiments confirmed that the rapid antidepressant-like effects require activation of AMPA receptors, not inhibition of NMDA receptors.

Oväntat och mycket spännande, vidare:

This paper predicts that it would have a similar, very rapid onset of action and efficacy against treatment resistant depression to ketamine, but that it would lack some of the undesirable side effects such as percetual [sic] distortion and addiction potential

http://www.dailymail.co.uk/health/article-3573549/Secret-ketamine-eases-depression-unlocked-scientists-raising-hopes-new-faster-acting-antidepressants.html

#NMDA #AMPA #läkemedel #depression #ketamin