7 träffar

Vitamin D-brist en riskfaktor för schizofreni?

Antiinflammatorisk behandling förbättrar kognition hos personer med Schizofreni

Cognition may improve significantly in schizophrenia patients when they are given anti-inflammatory treatment along with standard schizophrenia therapy, according to researchers at the Medical College of Georgia at Augusta University.

The new findings add to the growing body of evidence that at least some symptoms of schizophrenia are closely tied to the immune system and inflammatory reactions.

After only two intravenous doses of tocilizumab, an immune-suppressing drug typically prescribed for people with rheumatoid and juvenile arthritis, all five study participants with schizophrenia experienced improved cognitive ability.

En gen kan vara inblandad i flera allvarliga sjukdomar, bland annat bipolär sjukdom

The voltage-gated Cav1.2 calcium channels respond to membrane depolarization by increasing the membrane permeability to Ca2+, a major signal for cardiac muscle contraction, regulation of vascular tone and CREB-dependent transcriptional activation. CACNB2 is one of the four homologous genes coding for the auxiliary Cavβ subunits, which are important modulators of the Ca2+ channel activity. Five serious mental disorders - autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia, - and three major cardiovascular diseases - hypertension, heart failure and sudden cardiac death, - have recently been linked to the CACNB2 gene coding for the Cavβ2 subunits. Here I will focus on the Cavβ2-specific molecular determinant β2-CED as an emerging pharmacological target.

Det känns ju som att det är på riktigt fast det inte är det - om psykos

Bipolär sjukdom en del av ett "schizofrenispektrum"?

Ny roll för dopamin i sociala beteenden hos möss

The study published today in Cell explores a group found in a particular area of the brain called the dorsal raphe nucleus.

The researchers used optogenetics to show that when this group of dopamine neurons is activated in mice this prompts the animal to interact with others. The finding could hold important clues about how isolation affects people. “Social interactions are no doubt important for our mental health and play a role in conditions such as schizophrenia and depression. Interestingly, these disorders are also associated with dysfunction of dopamine neurons,” said Ungless. “We’re less likely to be able to help with such conditions if we continue to assume that all dopamine neurons do the same thing.”

Neurobiologisk analys av olika psykossjukdomar